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101 Best Business Information Systems Startups in United States of 2021

This article showcases our top picks for the best United States based Business Information Systems companies. These startups and companies are taking a variety of approaches to innovating the Business Information Systems industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

Top United States Business Information Systems Startups

Data sourced from Crunchbase and SemRush.

Neo4j

Neo4j

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Neo4j is the leader in graph technology. We help global brands to reveal and predict how people, processes & systems are interrelated.

IBM

IBM

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IBM is an IT technology and consulting firm providing computer hardware, software, infrastructure, and hosting services.

IBM

Skedulo

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Skedulo is a workforce management and scheduling platform for deskless workers.

IBM

SendGrid

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SendGrid is a cloud-based customer communication platform that drives engagement and business growth.

IBM

Instabase

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Instabase provides a broad technology platform, and an app store for businesses applications.

IBM

6sense

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6sense is an account engagement platform that helps B2B organizations achieve predictable revenue growth.

IBM

Bloomberg

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Bloomberg provides news, data, analytics, and communication services for the global business and financial world.

IBM

Tomorrow.io

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Tomorrow.io is a weather intelligence platform that provides real-time weather forecasts.

IBM

Observe

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Observe provides performance management tools based on a versatile observability platform.

IBM

Nuvolo

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Nuvolo is an integrated workplace management system that allows customers to manage their operations through a single platform.

IBM

Owler

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Owler is a business information and insights platform that provides company data and real-time news updates on various companies.

IBM

SparkPost

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SparkPost is an email delivery and optimization platform that helps companies send and analyze their email communications.

IBM

Kyruus

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Kyruus delivers search and scheduling solutions for health systems to match patients with the right providers across the access points.

IBM

Striim

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Striim is an enterprise-grade streaming data integration and operational intelligence platform.

IBM

ZenBusiness

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Zenbusiness offers business products and services that help business owners in starting, running, and growing a business.

IBM

Noteable

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Work With Data The Way You Want

IBM

K2

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K2 is a low-code digital process automation in the cloud.

IBM

Zoomin Software

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Zoomin Software helps companies manage their technical content such as user guides, manuals, and community discussions.

IBM

SetSchedule

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Your Voice Your Business, SetSchedule is Revolutionizing Business Development Using SAAS, Mobile And Marketplace Products.

IBM

Infinitus Systems

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Infinitus is a startup company that develops voice robotic process automation tools for the health care industry.

IBM

Catalytic

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Catalytic offers the easiest platform for digital transformation and the automation of knowledge work.

IBM

Candex

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Candex is a fintech vendor that engages track and pays for any good or service.

IBM

Flutura

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Flutura is an AI solutions company focused on improving two core business objectives – “Asset Uptime” and “Operational Efficiency” .

IBM

Zephyr

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Zephyr provides on-demand enterprise test management software.

IBM

Odaseva

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Odaseva is the leading Enterprise Data Platform for Salesforce offering powerful tools to keep Salesforce data protected

IBM

EverythingBenefits

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EverythingBenefits is a developer of a cloud-based business software used to help businesses increase profits.

IBM

Kissflow

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Kissflow is a leading SaaS software provider in the work management space.

IBM

Logiwa

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Logiwa is the industry-leading WMS serving retail, e-commerce, wholesale, and 3PL businesses worldwide for over a decade.

IBM

Coursedog

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Coursedog is an internet company that provides curriculum and schedule planning solutions for Higher Education.

IBM

Publicis Sapient

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Publicis Sapient is a digital transformation platform.

IBM

Drillinginfo

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Drilling Info accelerates workflows and business critical decision processes in oil and gas industry.

IBM

Factal

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Factal provides information to protect people, avoid disruptions and drive automation when the unexpected happens.

IBM

Databox

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Databox is an application that operates as a personal data assistant for businesses.

IBM

Ricult Inc.

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Ricult is a Data Science company that develops AI/Data/Tech/Financial-based digital solutions for the agricultural ecosystem.

IBM

Polarity

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Polarity is a computer software company that specializes in the fields of information technology and the internet.

IBM

ZypMedia

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ZypMedia is a programmatic media buying platform for local advertising.

IBM

REACH

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REACH reinvents digital customer experience by allowing companies to conduct remote transactional meetings with clients

IBM

HPIL Holding

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HPIL Holding is a diversified holding company listed on OTC Markets.

IBM

Release

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Release simplifies development by making the creation of environments easy.

IBM

Hub

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Hub is a blockchain based trust protocol that allows people to earn and carry their reputation data across Internet.

IBM

Willdan

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Willdan is a company selling professional technical and consulting services to public agencies at all levels.

IBM

Next Force Technology

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Next Force Technology is building an on-demand service for businesses, focused on a large and critical area that is untapped.

IBM

Preveta

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Preveta creates a data-driven cancer care coordination platform for health care providers focused on improving patient outcomes.

IBM

Tallyfy

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Tallyfy is beautiful workflow software that lets you document, track and improve all your repeatable processes

IBM

Eccentex Corporation

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Eccentex AppBase is a low-code platform that enables brands and governments to rapidly develop powerful digital applications.

IBM

RecovHub

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SaaS, B2B, B2C, Cloud, CRM, Lead Generation, Healthcare, Information Systems, Search Engine

IBM

Phosphorus

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Phosphorus Cyber Security, Inc.

IBM

Applied XL

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Business intelligence, Information systems, News automation, machine learning, life sciences

IBM

TraDove

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TraDove, Inc. is a social networking site focused on business to business marketing.

IBM

RankScience

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SEO Split Testing Platform & Services for Data Driven Companies

IBM

SumRidge Partners

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SumRidge Partners operates as a fixed income trading company.

IBM

Rimsys Regulatory Management Software

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Rimsys is a provider of Regulatory Information Management (RIM) software for medical technology companies.

IBM

DotAlign

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DotAlign provides software for relationship intelligence and inbox productivity.

IBM

Omnidek

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Omnidek provides business relationship management solutions for businesses to communicate with one another.

IBM

Smith-Cooper International

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Smith-Cooper provides pipe, valves and fittings to a wide range of customers and end markets.

IBM

MCI World

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MCI World is a holding company that provides tech-enabled business services.

IBM

Definiti

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Definiti provides National Workers’​ Compensation Cost Containment services.

IBM

Appy

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AI software tools to boost SMEs & freelancers growth

IBM

Inc.com

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Everything you need to know to start and grow your business now.

IBM

Stir

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At Stir we set out to create a product with the goal of transforming the way people go out.

IBM

Eichiba

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Enterprise SAAS, Email Collaboration

IBM

Amply

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Amply is a cloud-based email delivery service. Amply’s analytics engine helps companies gain actionable insight around the email they send.

IBM

ProfileGorilla

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SIMPLIFIED – Credentialing, Compliance, and On-Boarding Solutions

IBM

Align Today

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Align is based around proven business management methodologies.

IBM

Bezlio

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Bezlio is a SaaS product that allows your mobile workforce to visualize your data and analytics from anywhere, on any device!

IBM

Vimocity

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Vimocity is a software company that provides a platform for workplace safety and HR and make the workflow hassle-free.

IBM

changeforce.ai

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Enterprise, SaaS, Management Consulting, Change Management, Business Transformation

IBM

CSRHub

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CSRHub provides access to corporate social responsibility and sustainability ratings and information on 18,000 companies.

IBM

Ants Technology

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Ants Technology provides information technology and software services for clients throughout the State of Texas.

IBM

100AM

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100AM is an event networking platform that allows simple creation of business cards using a variety of digital assets.

IBM

Midwest Energy Emissions

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Delivers patented, cost-effective mercury capture solutions to coal-fired power plants and other large industrial coal-burning units.

IBM

DMscore

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DMscore…the FICO of Digital Marketing. DMscore is your partner in maximizing your return on investment from digital marketing.

IBM

DocQ

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DocQ is a SaaS contract lifecycle management. It auto-populates contract templates from any source.

IBM

TRiiBE Networks

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TRiiBE Is A Custom Business Hardware Systems Provider Focused On Merchant Services

IBM

Aunalytics

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Aunalytics offers Aunsight, a data science platform that enables businesses to use large amounts of disparate data to solve problems.

IBM

EagleHawk

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EagleHawk improving physical asset management through drone enabled inspections and data analytics.

IBM

Empyreal Enterprises,LLC

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Empyreal Corporation specializes in providing much needed gap services in the Marijuana Industry and other high risk businesses.

IBM

Advizor Solutions

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Advizor Solutions is today’s leading provider of easy-to-use business analysis software.

IBM

Clickatell

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Clickatell creates a better world through technology, making commerce in chat accessible for everyone, everywhere.

IBM

CO-SENDER

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CO-SENDER is a multi-channel campaign management software.

IBM

SVOI

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Russian-speaking business community

IBM

Code SixFour

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The Code SixFour Benefits Consulting Cloud empowers insurance agents and benefits brokers to deliver better benefits outcomes to employers.

IBM

Indiana Sign & Barricade

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It is Indiana’s Leading Full Service Sign & Barricade Solution Provider.

IBM

Hive Tracks

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Hive Tracks delivers cloud-based software and data analytics products focuses on honey bee health,beekeeping optimization.

IBM

Heroic

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Heroic is an app that builds beautiful websites that build your business too. A powerful combination of beauty *and* brains.

IBM

Teneo

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A New York-based corporate advisory firm

IBM

JetHunter

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Global Distribution System for private jet market

IBM

HCDC

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Hamilton County Business Center is a business incubation program helping entrepreneurs in Greater Cincinnati build successful companies.

IBM

Elite Form

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Elite Form, a software company, helps athletic teams and other performance-oriented organizations improve speed, agility, power and metrics.

IBM

Informed360

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Informed360, through its cloud-base platform and device-friendly design, provides a flexible and intuitive platform for any organization.

IBM

Walker Innovation

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Walker Innovation Inc. developed and recently introduced Haystack IQ, a subscription-based service that helps companies, of all sizes.

IBM

Fulcrum Digital

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Fulcrum Digital is a leading business platform and digital engineering services company.

IBM

Adia

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Our platform helps jobseekers find flexible work opportunities easily while giving employers access to great talent whenever they need.

IBM

The Jacksonville Bank

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The Jacksonville Bank provides community banking services to businesses and individuals.

IBM

Sortly

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Sortly is the leading “mobile centric” inventory platform that is simplifying how businesses and consumers keep track of their stuff.

IBM

Advanced Technology Services

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Advanced Technology Services makes business run better through optimizing enterprise assets.

IBM

Shareable Social

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Social Media Content on Cruise Control

IBM

Data.com International

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Data.com International is a financial data provider that offers company profiles and business contacts.

IBM

Carvechi Technology

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Carvechi Technology (CT) is a minority-owned Managed IT Services and PaaSage a Big Data & Analytics Platform focused on Sports.

IBM

Guidewheel (formerly Safi)

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Guidewheel’s plug-and-play platform empowers any factory to reach sustainable peak performance. Good for business, good for the planet.

IBM

Clevertech

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Clevertech is a custom software and app development company that solves hard problems. Business & systems integration.

Written by Warren Tesla

My name is Tesla and I am the pseudonym used by The Stratup Pill's broad writing team.

About me: Founder, CEO, CTO, CFO, CMO, CISO, Director, Head of the Board, Head of the oversight board, Executive, Legal Council, Head of Hiring, HR Manager, Consultant.

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